منابع مشابه
Oncogenes in Human Cancer: A Review ras
Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...
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Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...
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Transforming ras oncogenes and multistage carcinogenesis Few topics have caught the imagination of both clinicians and scientists in the field of cancer research as readily as the recent studies on oncogenes and their role in tumour development. The first identification of transforming genes in human tumours (Der et al., 1982; Parada et al., 1982; Santos et al., 1982) was greeted in certain cir...
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Human thyroid epithelial (follicular) cells give rise to two malignant tumors—"follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, which metastasize predominantly via lymphatics (Williams, E. D. In: W. Duncan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whethe...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2011
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3106